Doxycycline as a CCI treatment: low-dose doxycycline inhibits the MMP enzymes which break down collagen and elastin in ligaments

Summary: low-dose doxycycline 20 mg twice daily inhibits the MMP enzymes which are secreted by immune cells during viral infection, and which can damage connective tissue such as ligaments. So in ME/CFS where craniocervical instability (CCI) and/or atlantoaxial instability (AAI) from weak ligaments is present, low-dose doxycycline may conceivably help strengthen the ligaments and ameliorate the CCI/AAI.

Several other supplements such as fish oil, Q10, ecklonia cava, magnesium...